NEUROGENESIS ** Spore Synbiotic

Duanwood Reishi Spore Oil ( 30% Triterpenes )with Spore Forming Probiotcs ; B.Coagulans, B. Subtilis, B. Clausii (25 Billion CFU)

50ml Miron Glass Dropper Bottle

Reishi spore oil is a concentrated, lipid-soluble extract from cracked-shell Ganoderma lucidum spores, rich in bioactive triterpenes. Preliminary research suggests it may aid oral health by reducing periodontal inflammation and alveolar bone loss. It is primarily used for immune system modulation and stress reduction, with a 2000:1 concentration ratio. a

Key Considerations for Reishi Spore Oil

• Oral Health Potential: Studies indicate Reishi spore oil can decrease inflammatory factors like interleukin-8 (IL-8) and matrix metalloproteinase-1 (MMP-1) in gum tissue, potentially helping with periodontal (gum) disease.

Spore-based probiotics, such as Bacillus species, are highly stable bacteria that offer a promising, natural approach to oral health by restoring oral microbiome balance. They help reduce harmful bacteria responsible for cavities, plaque, and bad breath (halitosis) while promoting healthy gums and supporting healing after dental procedures.

Key Benefits of Spore Probiotics for Oral Health:

• Reduced Cavities & Plaque: Certain strains can outcompete cavity-causing bacteria like
  Streptococcus mutans.
• Antibacterial Effects: Bacillus strains can produce natural, antimicrobial compounds, and are resistant to environmental stressors,
  making them more stable than traditional probiotics.
• Improved Gum Health: They help reduce inflammation associated with gingivitis and periodontitis.
• Reduced Bad Breath: By lowering levels of odor-causing, anaerobic bacteria.

• Spore-based probiotics, such as Bacillus species, are highly stable bacteria that offer a promising, natural approach to oral health by restoring oral microbiome balance. They help reduce harmful bacteria responsible for cavities, plaque, and bad breath (halitosis) while promoting healthy gums and supporting healing after dental procedures.

  Key Benefits of Spore Probiotics for Oral Health:

  • Reduced Cavities & Plaque: Certain strains can outcompete cavity-causing bacteria like
    Streptococcus mutans.
  • Antibacterial Effects: Bacillus strains can produce natural, antimicrobial compounds, and are resistant to environmental stressors,
    making them more stable than traditional probiotics.
  • Improved Gum Health: They help reduce inflammation associated with gingivitis and periodontitis.
  • Reduced Bad Breath: By lowering levels of odor-causing, anaerobic bacteria
• Spore-based probiotics, particularly strains like Bacillus subtilis, support neurogenesis and brain health by acting through the gut-brain axis to reduce inflammation, strengthen the gut barrier, and increase short-chain fatty acid (SCFA) production. These probiotics can survive harsh gastrointestinal conditions to modulate immune responses and promote neural growth factors. 
  Key Mechanisms Supporting Neurogenesis
  • Reduced Neuroinflammation: Spore-based probiotics reduce systemic and chronic inflammation by balancing cytokines (e.g., lower levels of IL-12p70, IL-1β). Lowered inflammation reduces neuroinflammatory responses that impair cognitive function.
  • Production of SCFA: These probiotics, such as Clostridium butyricum, produce short-chain fatty acids (SCFAs) like butyrate, which promote the growth and differentiation of human neural progenitor cells.
  • Gut-Brain Axis Signaling: They improve gut integrity ("leaky gut"), which prevents toxins from entering the bloodstream and causing brain inflammation.
  • Neuroprotective Effects: Certain spore-forming strains, such as B. subtilis, have been linked to the modulation of gut microbiota, which in turn regulates the production of neurotransmitters and neurotrophic factors, crucial for neuroplasticity. 
  Evidence in Neurodegenerative Studies
  • Clostridium butyricum has been shown to improve neurological deficits and encourage the restoration of neurons in models of injury.
  • Research suggests that spore-based probiotics might help manage symptoms in neurodegenerative diseases like Alzheimer's and Parkinson's.
  • A recent study indicated that a combination of probiotics restored adult neurogenesis in germ-free mice.
• Reishi spore oil (and related Ganoderma lucidumextracts) promotes neurogenesis, specifically by increasing neural progenitor cell (NPC) proliferation and self-renewal. Rich in triterpenes and polysaccharides, it acts as a potent antioxidant and anti-inflammatory agent, protecting neurons from damage and enhancing cognitive function, particularly in models of Alzheimer's. 
  Key Neurogenesis & Brain Health Effects
  • Neural Progenitor Cell (NPC) Growth:Ganoderma lucidum polysaccharides (GLP) can increase NPC proliferation in the hippocampus, which is critical for learning and memory.
  • Neuroprotection: The oil protects brain cells from amyloid-beta toxicity (associated with Alzheimer's) and helps preserve dopamine-producing neurons, offering potential protection against Parkinson's disease.
  • Anti-inflammatory Mechanisms: Reishi reduces oxidative stress-induced damage and modulates inflammatory cytokines, aiding in overall brain cell survival and cognitive stability.
  • Enhanced Neurogenesis: Studies show increased numbers of BrdU/NeuN double-positive cells in the hippocampus, a marker for increased neurogenesis. 
  Reishi Spore Oil Benefits
  • Concentrated Essence: Reishi spore oil is highly concentrated in bioactive triterpenes and nucleosides, designed for enhanced absorption.
  • Key Bioactives: The oil is rich in triterpenoids, which can help promote calmness, reduce stress, and support neurological health.
  • Clinical Potential: It is considered a promising therapeutic agent for neurodegenerative diseases and general age-related cognitive decline.